Fig. 5.

Ixabepilone causes dramatic reduction in tumour growth in orthotopic sonic hedgehog (SHH) medulloblastoma. a Tumour growth was monitored by bioluminescence following treatment with ixabepilone or vehicle in mice bearing BT084 SHH orthotopic tumours. Tumour measurements were compared between vehicle and drug treatments using linear mixed models analysis in R. Treatment days are indicated by vertical lines on the graph. Representative H and E images of ixabepilone-treated mice (b) at 171 and vehicle-treated mice (c) at 29 days post-treatment. Scale bar 1 mm