Table 2.
Serial Changes in RV LGE and Functional Parameters
| Initial CMR | Latest CMR | p-value | |
|---|---|---|---|
| Group 1 (n = 84) | |||
| RVEDVI (ml/m2) | 134.5 (114.0, 150.0) | 133.9 (117.1, 152.1) | 0.013 |
| RVESVI (ml/ m2) | 65.7 (55.1, 81.3) | 72.0 (60.8, 84.9) | < 0.001 |
| RVEF (%) | 49.3 (45.8, 54.8) | 47.6 (41.4, 51.5) | < 0.001 |
| PR fraction (%) | 29.0 (7.0, 40.0) | 33.0 (9.0, 43.0) | 0.002 |
| RV LGE score | 4 (3, 5) | 3 (2,4) | < 0.001 |
| RV LGE extent (%) | 5.5 (3.4, 8.0) | 3.1 (2.0, 4.6) | < 0.001 |
| RV Mass/BSA, g/m2 | 16.6 (14.0, 19.4) | 16.6 (14.7, 19.0) | 0.652 |
| RV Mass:Volume, g/ml | 0.12 (0.10, 0.16) | 0.12 (0.10, 0.15) | 0.318 |
| Group 2 (n = 43) | |||
| RVEDVI (ml/m2) | 175.7 (141.6, 200.4) | 118.7 (102.2, 144.3) | < 0.001 |
| RVESVI (ml/ m2) | 85.6 (67.8, 106.1) | 63.8 (51.5, 82.8) | < 0.001 |
| RVEF (%) | 50.1 (42.7, 55.0) | 46.0 (40.7, 50.5) | 0.013 |
| PR fraction (%) | 46.0 (30.0, 55.0) | 5.0 (0.0, 13.0) | < 0.001 |
| RV LGE score | 4 (2, 5) | 3 (2, 4) | 0.030 |
| RV LGE extent (%) | 4.4 (2.7, 7.7) | 3.9 (2.6, 6.3) | 0.009 |
| RV Mass/BSA, g/m2 | 19.1 (14.9, 22.5) | 14.7 (12.5, 16.8) | < 0.001 |
| RV Mass:Volume, g/ml | 0.11 (0.09, 0.12) | 0.12 (0.09, 0.14) | 0.018 |
Variables are expressed as median (interquartile range). Group 1—patients with no interventions between serial CMRs; Group 2—patients with transcatheter or surgical interventions between CMRs. Median time between initial and latest CMR was 4.3 years (IQR 2.9, 6.6) for Group 1, and 2.7 years (IQR 1.6 to 5.3) for Group 2). BSA body surface area, CMR cardiovascular magnetic resonance, EDVI end-diastolic volume index, ESVI end-systolic volume index, EF ejection fraction, PR pulmonary regurgitation, LGE late gadolinium enhancement, RV right ventricle