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. 2021 Jun 21;40:203. doi: 10.1186/s13046-021-01989-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — OICR-9429 inhibits bladder cancer cell proliferation by regulating the cell cycle. a. Cell viability was evaluated in T24, UM-UC-3, and TCCSUP BCa cells treated with OICR-9429 or DMSO for 5 days. b. The images and quantification of colony formation assays in three BCa cells treated with two OICR-9429 doses or DMSO. c. Representative images and quantification of the cell cycle in three BCa cells treated with OICR-9429 or DMSO for 48 h. The percentages (%) of cell populations at different stages of the cell cycle are listed in the panels. d. EdU assay measurement of the cell population in S phase and a histogram analysis of EdU-positive cell counts are shown. Blue indicates the nucleus; red indicates S-phase cells. Scale bars, 50 μm (white). *p < 0.05 and **p < 0.01