Fig. 2.

Figure represents metabolic implications of EBV and proteasome dysregulation in NPC. Green arrows illustrate intracellular activation pathways. Red arrows show intracellular inhibitory pathways. Blue and black lines highlight initial and conclusive points of the pathways. A Biosignaling pathways associated to EBV infection and proteasome dysregulation in NPC cells. B Therapeutic implications of proteasome inhibitors in the molecular pathogenesis of NPC. **FBXO2 accounts for multimeric SKP1/Cul1/F-box