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. 2021 Jun 21;10:20. doi: 10.1186/s40035-021-00242-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Distribution of phosphorylated α-syn in the lumbar spinal cord after injection of different α-syn strains. a Immunohistochemistry for pSer129 α-syn demonstrated α-syn pathology in the spinal cord among different groups. High magnification showed that pSer129 α-syn in motor neurons was mainly located in the lumbar spinal cord. α-Syn aggregation was present in neurites (arrows) and in cell bodies (asterisks). Scale bar, 10 μm. b–d Semi-quantitative analyses of pSer129 α-syn intensity (immunohistochemical staining) in the whole ventral part and areas of the lumbar spinal cord where motor neurons are mainly located (one-way ANOVA with Tukey’s multiple comparison tests, n = 3, *P < 0.05, **P < 0.01, ***P < 0.001). e Comparison between the ipsilateral and contralateral sides in the lumbar spinal cord in Strain B group. Scale bar, 50 μm. f Statistical analysis by unpaired t-test (n = 3, P > 0.05). Mean ± SD