Table 1.

Data used for the Mendelian randomization analysis. For CAD and T2D participant numbers were split into cases and controls. *Reproducibility of spirometry measurement using ERS/ATS criteria; **European ancestry; ***Stage 1 meta-analysis

Trait	Source	Year	Imputation panel	N	Trait transformation
FEV1	UKBB & Wain et al. [19]	2017	HRC	270381*	Raw, in liter
FVC	UKBB & Wain et al. [19]	2017	HRC	270381*	Raw, in liter
FEV1/FVC	UKBB & Wain et al. [19]	2017	HRC	270381*	Raw, in liter
BMI	Locke et al. [8]	2015	HapMap2	322154**	Rank inverse normal transformed (BMI~age + age^2 + sex)
T2D	Scott et al. [9]	2017	1kG	26676 (132532)	Case control
CRP	Dehghan et al. [10]	2011	HapMap2	82725	ln(hsCRP)
HDL	Willer et al. [11]	2013	HapMap2	188577	Rank inverse normal transformation (HDL~age+age2+sex)
LDL	Willer et al. [11]	2013	HapMap2	188577	Rank inverse normal transformation (LDL~age+age2+sex)
TC	Willer et al. [11]	2013	HapMap2	188577	Rank inverse normal transformation (TC~age+age2+sex)
TG	Willer et al. [11]	2013	HapMap2	188577	Rank inverse normal transformation (TG~age+age2+sex)
SBP	Wain et al. [12]	2017	1kG	150134***	Residuals of (SBP~sex + age + age^2 + BMI)
DBP	Wain et al. [12]	2017	1kG	150134***	Residulas of (DBP~sex + age + age^2 + BMI)
PP	Wain et al. [12]	2017	1kG	150134***	Residuals of (PP~sex + age + age^2 + BMI)
CAD	Nikpay et al. [13]	2015	1kG	60801 (123504)	Case control