Fig 5.

Query results for immune-related diseases. (A) eQTL enrichment heatmaps of BioCarta pathways from three tissue types and 12 immune-related diseases. All 12 sets of immune diseases risk regions were queried against the BioCarta pathway collection in blood, thyroid and spleen tissue types, resulting in three heatmaps. In the heatmaps, each row represents a pathway, and each column represent a disease. IBD-specific pathways are marked with a red box. (B) eQTL enrichment heatmap of GO pathways. Queries were performed in the same way as in (A). Two enriched Biological Process GO terms are specific to psoriasis and CRO, which are highlighted with a red box. (C) Venn’s diagram of gene members of the two distinctly enriched pathways. Twenty-seven genes and 18 genes are targets of eQTLs found inside CRO and PSO disease risk regions, respectively. Among them, 14 genes are in common. Among these 14 shared genes, the ones have been reported in the literature as risk genes of both diseases are highlighted in red