Table 1.
Enriched pathway groups of psoriasis risk regions
| Group | Pathways | Shared eGenes |
|---|---|---|
| 1 | Keratinization (50)a | LCE3C, LCE3D, LCE3E LCE1E, LCE3A |
| Peptide cross linking (56) | ||
| 2 | Negative regulation of cell killing (18) | HLA-B, MICA, LGALS9 |
| Regulation of cell killing (63) | ||
| Negative regulation of innate immune response (38) | ||
| Regulation of leukocyte-mediated immunity (53) | ||
| Negative regulation of natural killer cell mediated immunity (12) | ||
| 3 | Antigen processing and presentation of endogenous peptide antigen (14) | HLA-B, ERAP2, HLA-C, ERAP1 |
| Antigen processing and presentation of endogenous antigen (17) |
a
The numbers of genes within each pathway is shown in the parenthesis.