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. 2021 Jun 7;12:660850. doi: 10.3389/fpsyt.2021.660850

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Copyright © 2021 Bustillo, Mayer, Upston, Jones, Garcia, Sheriff, Maudsley, Tohen, Gasparovic and Lenroot.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increased NAA in Schizophrenia (Sz) vs. Bipolar-I (BP) (healthy controls [HC] intermediate) in three clusters: (1) 114 voxels, CCLAV < 0.01, including the left lingual gyrus (29.9%) and left posterior cingulate (13.0%). (2) 61 voxels, CCLAV < 0.01, including the left precentral gyrus (34.7%%) and left middle frontal gyrus (22.1%). (3) 42 voxels, CCLAV = 0.05, including the right middle frontal gyrus (60.6%) and right precentral gyrus (10.2%). Boxplots shows weighted-average NAA cluster concentrations in institutional units.