Table 3b.

Multiple regression analysis of the relationships between Karnofsky score and diffusion metrics of all brain regions in the AAL atlas.

Regions	Effect	95% CI	P
Karnofsky score – White matter MD
Cerebral peduncle	-40.59	(-15.8, -65.38)	<0.01
Superior corona radiata	-84.7	(-28.04, -141.37)	<0.01
Posterior limb of internal capsule	-47.57	(-13.94, -81.2)	<0.01
Posterior corona radiata	-69.64	(-17.34, -121.94)	<0.05
Retrolenticular part of internal capsule	-50.61	(-12.44, -88.78)	<0.05
External capsule	-54.93	(-9.4, -100.46)	<0.05
Superior longitudinal fasciculus	-67.26	(-9.26, -125.27)	<0.05
Karnofsky score – White matter MK
Superior longitudinal fasciculus	96.26	(173.9, 18.61)	<0.05
Cerebral peduncle	66.64	(122.41, 10.87)	<0.05
Posterior corona radiata	91.83	(169.67, 13.98)	<0.05
External capsule	127.46	(237.96, 16.97)	<0.05
Superior corona radiata	83.21	(155.57, 10.84)	<0.05
Uncinate fasciculus	94.75	(179.01, 10.48)	<0.05
Posterior limb of internal capsule	58.17	(112.56, 3.78)	<0.05
Superior fronto-occipital fasciculus	47.1	(91.38, 2.82)	<0.05
Karnofsky score – White matter FA
Retrolenticular part of internal capsule	143.8	(233.52, 54.08)	<0.01
External capsule	175.26	(295.97, 54.55)	<0.01
Posterior limb of internal capsule	96.49	(172.27, 20.72)	<0.05
Uncinate fasciculus	111.13	(199.23, 23.02)	<0.05
Cerebral peduncle	97.69	(175.68, 19.7)	<0.05
Posterior thalamic radiation	156.4	(284.46, 28.34)	<0.05
Superior longitudinal fasciculus	168.56	(308.32, 28.79)	<0.05
Fornix	106.65	(196.4, 16.9)	<0.05
Karnofsky score – Grey matter MD
Pallidum	-37.01	(-9.83, -64.2)	<0.05
Putamen	-57.12	(-11.58, -102.66)	<0.05
Thalamus	-39.31	(-7.17, -71.45)	<0.05
Rolandic operculum	-38.88	(-2.93, -74.82)	<0.05
Inferior temporal gyrus	-72.11	(-1.85, -142.37)	<0.05

MD, mean diffusivity; MK, mean kurtosis; FA, fractional anisotropy.