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. 2021 Jun 7;11:655302. doi: 10.3389/fonc.2021.655302

Figure 1.

Figure 1

CD155 expression is up-regulated in patients with cervical cancer and HSIL and is positively correlated with Ki67 expression. (A) Distribution of serum CD155 levels CD155 in healthy women (n=17), HSIL patients (n=20) and cervical cancer patients (n=30). (B, C) Receiver operating characteristic (ROC) curve analysis of normal versus cervical cancer tissues and normal versus cervica cancer + HSIL tissues. The area under the ROC curve (AUC) was calculated for the diagnosis of cervical cancer. (D) Validation of CD155 expression in three GEO datasets: GSE67522, GSE39001 and GSE29570. CD155 mRNA levels were compared using Student’s t-test in the “limma” software package. (E) Representative images of CD155 immunohistochemistry (IHC) staining in normal cervical tissue (n = 18), HSIL tissue (n=20), and cervical cancer tissue (n=66). (F) Representative images of Ki67 IHC staining in cancer tissue (left: 100x, right: 200x). (G) CD155 expression was significantly positively correlated with the expression of Ki67 (r = 0.6608, P = 0.0004) in cervical cancers (data from IHC scores). NS, no significant. *P < 0.05, **P < 0.01, and ***P < 0.001.