Table 2.

Effect of gossypin and methotrexate on serum alanine transaminase and hepatic oxidative parameters of rats

Groups	Serum ALT (U/L)	Hepatic malondialdehyde (nmol/g tissue)	Hepatic glutathione reduced (nmol/g tissue)	Hepatic superoxide dismutase (U/g tissue)
Control	20.0±1.53	31.94±03.0	500.2±45.6	1213.0±062.7
Gossypin	22.0±0.60	28.55±00.6	488.5±33.1	1268.0±111.4
MTX	57.1±4.76*	78.39±18.6*	281.1±24.5*	0521.1±065.1*
MTX + gossypin	24.7±2.33#	37.07±03.9#	418.4±32.9#	1131.0±234.5#

*^,# Significantly different from the control group and MTX group, respectively, at P<0.05. All parameters are expressed as mean±SEM (n=6). MTX=Methotrexate, ALT=Alanine transaminase, SEM=Standard error of mean