Table 1.
Key features of AD associated lncRNAs
| LncRNA | Species | Length(nt) | 5ʹCap | Poly(A) tail | Splicing pattern | Protein binding partners | References |
|---|---|---|---|---|---|---|---|
| LoNA | M | 1516 | No | Yes | CS | NCL,FBL | [145] |
| LRP1-AS | H/M | 645/1387 | Yes | Yes | CS,ES | Hmgb2 | [58] |
| BACE1-AS | H/M | 840/2025 | Yes | Yes | CS,A5’SS,A3’SS | HuD | [82] |
| Sox2OT | H/M/R | 3132/2998/722 | Yes | Yes | CS,ES,A5’SS,MECE | FUS,YY1 | [103–105,146] |
| NEAT1 | H/M | 3756/3190 | Yes | Yes | IR,A5’SS,A3’SS | NONO,SFPQ,PSF,Ezh2 | [113,116,147,148] |
| MALAT1 | H/M | 8545/6983 | Yes | No | IR,A5’SS,A3’SS,MECE | SRSF1,SFPQ | [121,149] |
| SNHG1 | H/M | 1137/476 | Yes | Yes | IR,ES,A5’SS,A3’SS,MECE | MATR3,Ezh2 | [108,150,151] |
| BDNF-AS | H | 1437 | Yes | Yes | IR,ES,A5’SS,A3’SS,MECE | PABPC1 | [93,152] |
| BC200 | H | 200 | No | No | N/A | PABP | [133,134,138] |
| 51A | H/M | 300 | No | No | N/A | unknow | [66] |
| GDNFOS | H | 1550 | Yes | Yes | IR,ES,MECE | unknow | [69] |
| EBF3-AS | H/M | 842 | Yes | Yes | CS | unknow | [99] |
| NAT-RAD18 | R | 509 | No | No | N/A | unknow | [109] |
| NDM29 | H | 1584 | No | No | N/A | unknow | [51,52] |
H:human, M:mouse, R:rat, ES: exon skipping, IR: intron retention, A5’SS: alternative 5ʹ splice sites, A3’SS: alternative 3ʹ splice sites, CS: constitutive splicing, MECE: mutually exclusive exon