Table 1.

Dysregulated A-to-I editing associated with neurological or neurodegenerative diseases

Gene	Editing site	Responsible ADAR1/2	Editing function	Associated disease
GRIA2	GluA2 Q→R	2	Change in Ca2+ permeability	Amyotrophic lateral sclerosis (ALS) [32,34,39] Epilepsy [30,45] Developmental epileptic encephalopathy (DEE) [48–50] Astrocytoma [55,56]
HT2CR	5-HT2cR A, B, D sites	1	Decrease in 5-HT potency Reduction in G protein-coupling efficiency	Depression [68,70] Suicide Schizophrenia [69,70] Bipolar disorder [70,71]
	5-HT2cR C, E sites	1, 2
KCNA1	Kv1.1 I→V	2	Reduction in the deactivation rate	Episodic Ataxia Type 1 (EA1) [81], Epilepsy [77]
MIR21	pri-miR-21 8 sites	2	Inhibit Drosha processing	Astrocytoma [137]
MIR221	pri-miR-221 − 1, +1, +64	2	Inhibit Drosha processing	Astrocytoma [137]
MIR222	pri-miR-222 − 21, +53	2	Inhibit Drosha processing	Astrocytoma [137]
MIR376A	pri-miR-376a +9	2	Redirection of target recognition of mature miRNA	Astrocytoma [138]