Table 2.

Correlation coefficients of global 5hmC, H3K4me3, H3K9me3, and H3K27me3 with characteristics of lean and obese pigs and their MSC function (n = 14)

MSC and pig characteristics	5hmC	H3K4me3	H3K9me3	H3K27me3
Body weight (kg)	–0.594	–0.740*	–0.138	0.236
Heart rate (beat/minute)	0.166	0.245	0.132	–0.405
Systolic blood pressure (mmHg)	–0.199	0.264	–0.470	–0.130
Diastolic blood pressure (mmHg)	0.227	0.489	–0.356	0.149
Mean arterial pressure (mmHg)	0.118	0.469	–0.454	0.076
Glucose (mg/dL)	0.377	–0.349	0.373	–0.055
Insulin (µU/ml)	0.094	–0.507	0.699*	0.050
HOMA-IR	0.200	–0.571	0.667*	0.127
Total cholesterol (mg/dL)	–0.732*	–0.717*	–0.052	0.329
HDL-C (mg/dL)	–0.669*	–0.680*	–0.106	0.151
LDL-C (mg/dL)	–0.721*	–0.721*	–0.044	0.345
Triglycerides (mg/dL)	–0.300	0.296	0.214	–0.103
VLDL (mg/dL)	–0.300	0.296	0.214	–0.103
MSC Proliferation	0.769*	0.696*	0.276	0.011
MSC Migration	0.750*	0.190	0.083	–0.152

Abbreviations: MSC: Mesenchymal stem cells; 5hmC: 5-hydroxymethycytosine; H3K4me3: histone 3 protein tri-methylation on lysine 4 residue; H3K9me3: histone 3 protein tri-methylation on lysine 9 residue; H3K27me3: histone 3 protein tri-methylation on lysine 27 residue; HOMA-IR: Homoeostatic Model Assessment of Insulin Resistance; HDL-C: High-density lipoprotein cholesterols; LDL-C Low-density lipoprotein cholesterols; VLDL: Very low-density lipoproteins.

*p ≤ 0.05.