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. 2021 Jun 7;11:688007. doi: 10.3389/fcimb.2021.688007

Figure 5.

Figure 5

Histopathology of the lungs of mice inoculated with PBS (A), WT (B), or MA-P5 (C). The HE score results are shown in (D). The infected mouse lungs were fixed with formalin, embedded in paraffin and stained with hematoxylin and eosin. Images were obtained at 20× magnification; arrow a, lymphocytes; arrow b, neutrophils; arrow c, bleeding. Pathological severity scores in infected mice, based on the inflammation area percentage for each section of the lungs collected from each animal using the following scoring system: 0, no pathological change; 1, affected area ≤ 10%; 2, affected area < 50% and > 10%; and 3, affected area ≥ 50%; an additional point was added to the score when pulmonary edema and/or alveolar hemorrhage was observed. *P < 0.05 (MA-P5 vs WT).