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. Author manuscript; available in PMC: 2021 Jun 21.
Published in final edited form as: J Huntingtons Dis. 2020;9(1):47–58. doi: 10.3233/JHD-190391

Table 3.

Estimates of rate of change (slope) in Total Functional Capacity score by categorical baseline variables

Characteristic Slope 95% CI p
Sex
 Female −0.91 (−1.00, −0.82)
 Male −0.75 (−0.84, −0.67)
 Difference 0.16 (0.04, 0.28) 0.01
Marital status
 Never married −0.97 (−1.13, −0.81)
 Married −0.85 (−0.92, −0.77)
 Separated/widowed/divorced −0.72 (−0.84, −0.59)
Difference
 Never married vs. separated/widowed/divorced −0.25 (−0.05, −0.45) 0.05
 Never married vs. married −0.12 (−0.30, 0.06)
 Separated/widowed/divorced vs. married 0.13 (−0.02, 0.28)
Education level
 ≤ High school −0.86 (−0.94, −0.78)
 > High school −0.80 (−0.89, −0.71)
 Difference 0.06 (−0.07, 0.18) 0.35
Currently in the labor force
 No −0.84 (−0.91, −0.76)
 Yes −0.83 (−0.94, −0.72)
 Difference 0.01 (−0.13, 0.14) 0.93
History of alcohol abuse
 No −0.83 (−0.89, −0.77)
 Yes −1.50 (−2.22, −0.77)
 Difference −0.67 (−1.39, 0.06) 0.07
History of tobacco abuse
 No −0.82 (−0.89, −0.75)
 Yes −0.89 (−1.05, −0.74)
 Difference −0.07 (−0.24, 0.10) 0.40
Active psychiatric diagnosis
 Depression
  No −0.80 (−0.89, −0.71)
  Yes −0.86 (−0.95, −0.78)
  Difference −0.06 (−0.19, 0.06) 0.31
 Anxiety
  No −0.83 (−0.90, −0.76)
  Yes −0.83 (−0.96, −0.71)
  Difference 0.001 (−0.14, 0.14) 0.99
 Bipolar disorder
  No −0.83 (−0.89, −0.76)
  Yes −1.68 (−2.36, −1.00)
  Difference −0.86 (−1.54, −0.18) 0.01
 Depression or anxiety or bipolar disorder
  No −0.79 (−0.89, −0.70)
  Yes −0.86 (−0.94, −0.78)
  Difference −0.07 (−0.19, 0.06) 0.29
Medication use
 Antidepressant use
  No −0.82 (−0.91, −0.73)
  Yes −0.84 (−0.93, −0.76)
  Difference −0.02 (−0.15, 0.10) 0.70
 Anxiolytic use
  No −0.85 (−0.91, −0.78)
  Yes −0.75 (−0.92, −0.58)
  Difference 0.10 (−0.08, 0.28) 0.29
 Antidepressant or anxiolytic use
  No −0.82 (−0.91, −0.72)
  Yes −0.84 (−0.92, −0.76)
  Difference 0.03 (−0.15, 0.10) 0.68
History of suicidal ideation
 No −0.82 (−0.89, −0.75)
 Yes −0.93 (−1.10, −0.76)
 Difference −0.11 (−0.30, 0.08) 0.24
Marital status×employment status interaction
 Never married; not in the labor force −1.01 (−1.19, −0.82)
 Married; not in the labor force −0.85 (−0.94, −0.75)
 Separated/widowed/divorced; not in the labor force −0.70 (−0.85, −0.56) 0.68
 Never married; currently in the labor force −0.86 (−1.17, −0.56)
 Married; currently in the labor force −0.84 (−0.98, −0.71)
 Separated/widowed/divorced; currently in the labor force −0.77 (−1.02, −0.51)