Table 1:
Variables Used For Cluster Analysis
| Variables | |
|---|---|
| Demographics | - gender (male/female) |
| - race (white/non-white) | |
| Clinical Criteria For Definite Antiphospholipid Syndrome | - arterial thrombosis (yes/no)* |
| - venous thromboembolism (yes/no)* | |
| - biopsy-proven microvascular thrombosis (pulmonary, skin, kidney, and “other”) (yes/no)* | |
| - fetal death after 10th week of gestation (yes/no)* | |
| - premature birth due to preeclampsia, eclampsia, or placental insufficiency before 34th week of gestation (yes/no)* | |
| - three or more consecutive pre-embryonic or embryonic losses before 10th week of gestation (yes/no)* | |
| Non-Criteria Manifestations | - superficial vein thrombosis (yes/no) |
| - transient ischemic attack (yes/no) | |
| - livedo reticularis/racemosa (past or current/never) | |
| - persistent thrombocytopenia defined as platelets < 100,000x109 tested twice at least 12 weeks apart (past or current/never) | |
| - autoimmune hemolytic anemia (past or current/never) | |
| - echocardiography-proven heart valve disease (yes/no or unknown) | |
| - biopsy-proven aPL-related nephropathy (yes/no or unknown) | |
| - neuropsychiatric test-proven cognitive impairment (abnormal/normal or unknown) | |
| - chorea (yes/no) | |
| - seizure (yes/no) | |
| - skin ulcer (yes/no) | |
| - brain white matter abnormalities (yes/no or unknown) | |
| Cardiovascular Risk Factors | - body-mass index > 30 (yes/no)* |
| - hypertension requiring treatment (yes/no)* | |
| - diabetes mellitus requiring treatment (yes/no)* | |
| - hyperlipidemia requiring treatment (yes/no)* | |
| - smoking (past or current/never)* | |
| aPL Profile | - positive LA test (yes/no)* |
| - positive aCL IgG/IgM/IgA (yes/no)* | |
| - positive aβ2GPI IgG/IgM/IgA (yes/no)* | |
| Associated Auto-Immune Diseases | - SLE based on the American College of Rheumatology Classification Criteria (yes/no)* |
| - other autoimmune disease, e.g. lupus-like disease, rheumatoid arthritis, Sjogren’s syndrome, systemic sclerosis, idiopathic inflammatory myopathy, or vasculitis (yes/no) |
*
Variables used for the cluster analysis restricted to female aPL-positive patients with a history of pregnancy.
aβ2GPI: Anti-β2-Glycoprotein I antibodies; aCL: Anticardiolipin Antibodies; aPL: antiphospholipid antibodies; LA: Lupus Anticoagulant; SLE: Systemic Lupus Erythematosus.