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. 2021 Jun 18;10(1):1227–1240. doi: 10.1080/22221751.2021.1937329

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Inhibitory activity of IPB19-based lipopeptides against SARS-CoV-2. The inhibitory activities of IPB19-based lipopeptides on the SARS-CoV-2 S protein-mediated cell-cell fusion (A and C) and pseudovirus infections in 293T/ACE2 cells (B and E) or Huh-7 cells (C and F) were determined by DSP-based cell fusion assay and single-cycle infection assay, respectively. The inhibitory activity of three lipopeptides against live SARS-CoV-2 infection in Vero cells (G) as well as their cytoxicity on Huh-7 cells (H) or Vero cells (I) were respectively determined. The experiments were repeated three times, and data are expressed as the means ± SD.