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Broad-spectrum inhibitory activity of IPB19-based lipopeptides against divergent human CoVs. The inhibitory activity of IPB19 derivatives against the SARS-CoV (A), MERS-CoV (B), HCoV-NL63 (C) and HCoV-229E (D) pseudovirus infections in Huh-7 cells was determined by single-cycle infection assays. The experiments were repeated three times, and data are expressed as the means ± SD.
