Table 1.

Histone sumoylation sites and functions

Organism	Histone	aDiscovery	Sites	Function	Refs.
H. sapiens	H2A	2003		Transcriptional repression or chromatin compaction	(12,15,16)
	H2B	2003			(12,16)
	H3	2003	K18		(12,14–16)
	H4	2003	K12		(12,13,15,16,28,29)
	H2A.X	2013	K5, K9, K13, K15, K118, K119, K127, K133, K134		(15)
	H1	2009			(16)
S. cerevisiae	H2A	2006	bK126	Transcriptional repression/activation, inhibition of cryptic initiation	(17)
	H2B	2006	K6, K7, K16, K17		(17,31,40,45)
	H3	2006			(17)
	H4	2006	K5, K8, K12, K16, K20		(17,40,45)
	H2A.Z	2006	K126, K133	cDSB repair	(17,18)
	Cse4	2016	K65, K215, K216	Cse4 incorporation or proteolysis	(19,77,78)

^aThe first detected year of histone sumoylation.

^bH2A sumoylation level was not changed in an arginine substitution mutant of this site.

^cDSB: double-stranded break.