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PRC2 binding induces DNA bending. (A) Free energy profiles as a function of the DNA end-to-end distance for the pure DNA (black) and the DNA bound with PRC2b (red) or PRC2f (cyan). (B) The average DNA bending angle as a function of the number of contacts between PRC2 and the DNA. In both A and B, lines represent mean values, and shaded regions correspond to standard deviations of the mean. (C) Residue specific probability map for PRC2b (left) and PRC2f (right) contacting the DNA.
