Figure 5.

Cooperativity between the two PRC2f complexes arises from an allosteric communication mediated by the DNA. (A) Illustration of the DNA loops formed by the two PRC2f complexes. The collective variable, loop length, is defined as the contour length of the larger loop. (B) Two-dimensional free energy profile as a function of the DNA end-to-end distance and the loop length. (C) The average length of the dominant loop (red in part A) as a function of the number of contacts between the DNA and the PRC2f that forms the smaller loop (blue in part A). The shaded region represents standard deviation of the mean.