Figure 4.

Meta-analysis of the mortality rate according to the anticoagulation strategy (anti-Xa-guided vs time-guided). Overall, there was a lower mortality rate among anti-Xa-based anticoagulation series, bleeding occurring in 35.4% of the patients (Figure 4(a)) versus 42.9% of the patients in the time-guided studies (Figure 4(b)). Using a random-effect on the seven studies providing results from both strategies, there was significantly lower mortality rate in the anti-Xa-based anticoagulation strategy (adjusted OR 0.61, p < 0.03), Figure 4(c)).