Table 1.

Selection and classification (patient, disease and treatment parameters) of selected variables relevant for the second-line therapeutic choice and the relative ranking score and importance.

Patient-dependent parameters	Ranking score	Parameter importance
Symptomatology of the disease in the second line	12	1
Comorbidities (especially cardiovascular) and immuno-oncology (I-O) characteristic of the patient	13	2
Prognostic class: IMDC (International Metastatic RCC Database Consortium) risk score	23	3
Compliance and independent management of therapy and patient perception	24	4
Predictable need to use steroids in the short term	25	5
Patient motivation (respect the survival curve) and patient awareness of the therapy	29	6
Disease-dependent parameters	Ranking score	Parameter importance
Biological aggressiveness of the tumor e type of progression	14	1
Presence of the sarcomatoid component	20	2
Disease volume	23	3
Symptomatology of the disease in the second line	23	3
Prognostic class: IMDC (International Metastatic RCC Database Consortium) risk score	29	5
Predictable need to use steroids in the short term	34	6
Sites of metastases (in particular, presence of brain and liver metastases)	35	7
Histology	38	8
Treatment-dependent parameters	Ranking score	Parameter importance
Selection of the first line between TKI and immunotherapy	12	1
Objective of the second-line treatment	13	2
Onset of drug action	18	3
Duration of response to first-line therapy (TKI)	19	4
Toxicity of first-line treatment	22	5