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. 2021 Jun 18;11(3):20458940211025240. doi: 10.1177/20458940211025240

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© The Author(s) 2021

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig. 2. — Spironolactone but not selective MR blockade decreases cardiomyocyte size in experimental PH. Right ventricular hypotrophy as measured by the RV/LV + septum ratio (a) and cardiomyocyte (CM) size (b) were measured in mice described in Fig. 1. RV hypertrophy was consistently elevated in all hypoxic groups. Spironolactone produced a modest, but significant decrease in CM size. *p < 0.5; **p < 0.01; ***p < 0.001. N = 12–24/group for RV hypertrophy and N = 3–4 animals/group for CM size (30–40 cardiomyocytes per animal).

RV: right ventricular; LV: left ventricular; S: septum; SP: spironolactone; SMC: smooth muscle cell; MR: mineralocorticoid receptor; EC: endothelial cell.