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. 2021 Jun 7;12:649343. doi: 10.3389/fimmu.2021.649343

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Copyright © 2021 Li, Wang, Wu, Li, Zhang, Zhang, Xu, Sun and Jiao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlations between D50 index and progression-free survival rate in the discovery and validation cohorts. (A) ROC curve for the correlation of D50 index with response in the discovery cohort. AUC is 0.952. Cut-off of ≥3.09 D50 index is designated by triangle. (B) Correlations between D50 index and progression-free survival rate at post-treatment samples in the discovery cohort. (C) Correlations between D50 index and overall survival rate at post-treatment samples in the discovery cohort. (D) ROC curve for the correlation of D50 index with response in the validation cohort. (E) Correlations between D50 index and progression-free survival rate at post-treatment samples in the validation cohort. The survival curves were constructed using the Kaplan-Meier method and compared between groups classified by the D50 index in (B, D). Significance was analyzed by log-rank test.