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. 2020 Jul 5;27(1):1018–1033. doi: 10.1080/10717544.2020.1785583

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© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Ultrasound combined with PSP@MB to promote endocytosis of 155 kDa FITC-dextran into A2780 cells. (A) Fluorescent images of 155 kDa FITC-dextran into A2780 exposed via ultrasound and PSP@MB. The experimental groups were: (a) Control group, (b) PSP@MB group, (c) US group, (d) US + PSP@MB 0.2 W/cm² group, (e) US + PSP@MB 0.4 W/cm² group, (f) US + PSP@MB 0.6 W/cm² group, (g) US + PSP@MB 0.8 W/cm² group, and (h) US + PSP@MB 1.0 W/cm² group. The ultrasonic parameters were (1 MHz, 20% duty cycle, 1 min). (B) Fluorescence intensity was represented as histograms. Fluorescence intensity increased following the acoustic intensity increase. The relative fluorescence intensity was (16.87 ± 2.73) in the (h) group, higher than (e) group (7.53 ± 1.42) and (f) group (13.22 ± 1.85). Compared with the relative fluorescence intensity between (h) group and (g) group (14.82 ± 2.14), the difference was not statistically significant. *p < .05, **p < .01.