Figure 2.

(A) 3D binding and (B) 2D binding interactions of taurocholate to the ASBT taurocholate-binding site. (C) 3D binding and (C) 2D binding interactions of the co-crystallized lactose with the ASGPR carbohydrate-binding site. For A and C: Green = hydrophobic surface, purple = hydrogen bonding site, and blue = mild polar. Atoms color coding: gray = carbon, red = oxygen, blue = nitrogen, yellow = sulfur. For B and D: Hydrogen bonds and bonds to metals are shown as blue and green dashed arrows. Hydrogen bonds through water bridges are represented as brown dotted lines. Amino acids spheres: pink circled in red = acidic, pink circled in blue = basic, pink circled in black = polar, green circled in black = greasy.