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. 2020 Jun 9;27(1):864–875. doi: 10.1080/10717544.2020.1775724

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© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — (A) Viability and (B) cytotoxicity effects of immobilized siRNA nanoparticles after 1, 2, and 7 days. One-way ANOVA with a p-value < .05 (*) +was used to determine statistically significant difference and was only found between the positive control and results after 7 days of exposure. Nonetheless, viability levels were always kept above 80%, indicating acute and chronic biocompatibility. (C) BACE-1 relative expression in HFF-1 cells after cellular treatment with bare magnetite nanoparticles, PEG coated nanoparticles and immobilized siRNA nanoconjugates. Kruskal–Wallis analysis was used to determine significant difference (*) p < .05.