Figure 6.

In vivo co-administration of PPMO and OEC. EGFP654 mice received a single IV co-injection of PPMO654 at 7.5 mg/kg plus OEC UNC7938 or UNC2383 at 15 and 5 mg/kg respectively (n = 3-4 per group). After 48 h, mice were euthanized, and lung tissues recovered and analyzed by RT-PCR as before. (A, B) RT-PCR gel of lung tissues at 48 h post-treatment. (C) Lung RT-PCR band quantification, *P < 0.02 versus no OEC. Co-administration of PPMO and OEC is efficient in correcting the splicing defect in EGFP in vivo in lung epithelia.