Skip to main content
. 2021 Jun 9;49(11):6315–6330. doi: 10.1093/nar/gkab475

Figure 7.

Figure 7.

Proposed model of intra-domain looping in IC2 maintenance of imprinting. (A) On the maternal allele, interactions connect the 5′ end of KCNQ1, KCNQ1 intron2 and the 5′ end of CDKN1C, which promotes expression of both KCNQ1 and CDKN1C. This looping excludes the ICR. (B) On the paternal allele, low frequency contacts between the ICR and the 5′ end of KCNQ1 and KCNQ1 intron2 or the 5′ end of CDKN1C, but not all three. The result is expression of KCNQ1OT1. (C) On the maternal allele carrying the KCNQ1 5′ deletion, this interaction does not organize correctly. This may be caused by transcription disruption of KCNQ1, but leads to an interaction profile resembling the paternal allele and loss of CDKN1C expression.