Table 3.
Associated functions of up-regulated genes in T2 CRSsNP
| Association | Up-regulated gene in T2 CRSsNP compared to control ET |
|---|---|
| T2 inflammation | IL4, IL5, IL13, CCL13, CCL18, CCL23, CCL26 |
| IL-13 and STAT6 induced | CLCA1, POSTN, SERPINB2, SERPINB10, CST1, CST2, FETUB |
| Activation | CD69, IL2RA |
| Th2 and ILC2 | IL1RL1, PTGDR2 |
| Eosinophil | ALOX15, CLC, CCL13, CCL26, CCR3, HRH4, RNASE2, RNASE3, SIGLEC8, PRSS33, PTGDR2 |
| Mast cell | CPA3, HDC, MS4A2, HPGDS, TPSAB1, TPSD1 |
| Basophil | CLC, CCR3, PTGDR2 |
| Myeloid cell | CCR1, CCL8, CCL23, CD1C, CD163, CD200R1, CD209, CD300LF, CNR2, F13A1, MARCO, MRC1, NLRP12 |
| Regulatory T cell | IL2RA, FOXP3, IL10, CTLA4 |
| Group I CD1 | CD1A, CD1B, CD1C |