. Author manuscript; available in PMC: 2022 Apr 1.

Published in final edited form as: J Allergy Clin Immunol. 2020 Dec 14;147(4):1306–1317. doi: 10.1016/j.jaci.2020.11.037

Table 4.

Associated functions of up-regulated genes in T3 CRSsNP

Association	Up-regulated gene in T3 CRSsNP compared to control ET
Acute inflammatory and host defense	SAA1, SAA2, SAA4, HAMP, CFB, CP, DEFB4A, CHI3L1, S100A9, SERPINA1, SERPINA3
Complement	C1QA, C1QB, C1QC, C3, C4A, C4B, C4BPA, CFB
Proinflammatory cytokine	IL1B, IL6, IL17F, CSF3, LTB, TNFSF11, TNFSF14
Class II MHC-related	HLA-DMB, HLA-DOB, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB, HLA-DRB3, HLA-DRB4
Neutrophil	CSF3, CSF3R, CXCL1, CXCL2, CXCL3, CXCL6, CXCR1, CXCR2, IL-8, CD177, FCGR3A, FPR1, FPR2, FPR3, VNN2
Macrophage	AIM2, CCL2, CCL7, CCL8, CCR1, FCGR1B, CNR2, MMP12, MPEG1
B cell	CD19, CD22, CD72, CD79B, BLK, CXCL13
T cell	CD3D, CD7, CD27, CD28, CD40LG, CTLA4, ICOS, TIGIT