Table 1. Immunogenetics determined by Cloanalyst rhesus macaque library.
Vaccine | Macaque | Antibody | Macaque VH | Macaque JH | HCDR3 length (aa) | Macaque VL | Macaque JL | HCDR3 length (aa) |
---|---|---|---|---|---|---|---|---|
DNA/Ad5/Protein | L999 | DH840.1 | IGHV4-n | IGHJ4 | 15 | IGKV3-d | IGKJ4-1 | 8 |
DNA/Ad5/Protein | M172 | DH842 | IGHV4-n | IGHJ5-1 | 17 | IGLV5-e | IGLJ1 | 9 |
NYVAC-gp120 | 80–12 | DH845.1 | IGHV4-n | IGHJ1 | 20 | IGKV1-Ab | IGKJ2-1 | 9 |
NYVAC-gp120 | 80–12 | DH846.1 | IGHV4-n | IGHJ4 | 15 | IGKV3-d | IGKJ1-1 | 8 |