Table 3.

Associations of body mass index categories with categories of annual percent change in total kidney volume

End Point, Annual Percent Change in TKV	Model	5%–7% (n=170) versus <5% (n=715)	≥7% (n=345) versus <5% (n=715)	≥5% (n=515) versus <5% (n=715)
Normal weight, BMI=18.5–24.9 kg/m2		1 (Reference)	1 (Reference)	1 (Reference)
Overweight, BMI=25–29.9 kg/m2	Unadjusted	1.19 [0.82 to 1.73]	2.35 [1.74 to 3.16]	1.84 [1.42 to 2.37]
	Model 1	1.10 [0.75 to 1.61]	2.08 [1.52 to 2.84]	1.63 [1.25 to 2.14]
	Model 2	1.19 [0.80 to 1.76]	2.29 [1.65 to 3.19]	1.78 [1.34 to 2.36]
	Model 3	1.07 [0.71 to 1.61]	2.04 [1.45 to 2.87]	1.59 [1.19 to 2.13]
Obese, BMI≥30 kg/m2	Unadjusted	1.14 [0.68 to 1.92]	3.80 [2.65 to 5.43]	2.62 [1.89 to 3.63]
	Model 1	1.14 [0.68 to 1.94]	4.13 [2.83 to 6.02]	2.71 [1.93 to 3.80]
	Model 2	1.27 [0.74 to 2.19]	4.62 [3.08 to 6.93]	2.98 [2.08 to 4.27]
	Model 3	1.27 [0.72 to 2.22]	4.31 [2.83 to 6.57]	2.84 [1.95 to 4.13]
BMI as a continuous predictor variable, per five-unit higher BMI	Unadjusted	1.16 [0.97 to 1.14]	1.74 [1.53 to 2.01]	1.57 [1.42 to 1.73]
	Model 1	1.16 [0.96 to 1.41]	1.83 [1.54 to 2.08]	1.57 [1.42 to 1.73]
	Model 2	1.22 [1.00 to 1.49]	1.92 [1.57 to 2.33]	1.65 [1.49 to 1.82]
	Model 3	1.22 [1.00 to 1.49]	1.82 [1.50 to 2.22]	1.57 [1.29 to 1.91]

Reference group is an odds ratio of 1. Values are presented as odds ratios (95% confidence intervals). The unadjusted model was n=1230. Model 1 was adjusted for age, sex, and race/ethnicity (n=1230). Model 2 was adjusted for model 1 plus randomization group, systolic BP, and serum glucose (n=1230). Model 3 was adjusted for model 2 plus baseline eGFR (CKD Epidemiology Collaboration equation) and urinary microalbumin (n=1168 [n=680 for <5%, n=158 for 5%–7%, and n=330 for ≥7% annual percent change in total kidney volume]). TKV, total kidney volume; BMI, body mass index.