Table 3.
Quality of life, symptoms, and behavioral problems
| Questionnaire | PHQ-9 category score |
All women (n = 231) | Pa | ||
|---|---|---|---|---|---|
| <5 | 5-9 | 10+ | |||
| (n = 53) | (n = 106) | (n = 72) | |||
| SF-12 version 1: mean (SD) | |||||
| PCS | 51.6 (7.9) | 51.0 (8.6) | 46.3 (11.9) | 49.6 (9.9) | .003 |
| MCS | 47.0 (8.6) | 41.6 (8.3) | 31.5 (9.3) | 39.6 (10.5) | <.001 |
| FSI severity, possible range 0-10, mean (SD) | 3.3 (1.5) | 4.5 (1.4) | 5.6 (1.5) | 4.6 (1.6) | <.001 |
| Binary FSI severity, No. (%) | |||||
| <3 (not fatigued) | 21 (39.6) | 13 (12.3) | 2 (2.8) | 36 (15.6) | <.001 |
| 3 or more (fatigued) | 32 (60.4) | 93 (87.7) | 70 (97.2) | 195 (84.4) | |
| ISI, possible range 0-28, mean (SD) | 8.4 (4.5) | 12.1 (5.6) | 15.0 (6.9) | 12.1 (6.3) | <.001 |
| Categorical ISI, No. (%) | |||||
| No clinically significant insomnia (0-7) | 24 (45.3) | 25 (23.6) | 12 (16.7) | 61 (26.4) | <.001 |
| Subthreshold insomnia (8-14) | 24 (45.3) | 46 (43.4) | 18 (25.0) | 88 (38.1) | |
| Clinical insomnia, moderate severity (15-21) | 4 (7.6) | 30 (28.3) | 31 (43.1) | 65 (28.1) | |
| Clinical insomnia, severe (22-28) | 1 (1.9) | 5 (4.7) | 11 (15.3) | 17 (7.4) | |
| BCPT Symptom Scales, possible range 0-4, mean (SD) | |||||
| Hot flashes | 1.2 (1.2) | 1.4 (1.2) | 1.8 (1.5) | 1.5 (1.3) | .03 |
| Nausea | 0.1 (0.2) | 0.2 (0.4) | 0.3 (0.5) | 0.2 (0.4) | .02 |
| Bladder control | 0.2 (0.3) | 0.5 (0.8) | 0.8 (1.2) | 0.5 (0.9) | .006 |
| Vaginal problems | 0.6 (1.0) | 0.9 (1.2) | 1.1 (1.3) | 0.9 (1.2) | .12 |
| Musculoskeletal pain | 1.2 (1.0) | 1.4 (1.1) | 2.0 (1.2) | 1.6 (1.1) | <.001 |
| Cognitive problems | 1.0 (0.8) | 1.6 (0.9) | 2.6 (1.1) | 1.8 (1.1) | <.001 |
| Weight problems | 1.1 (1.0) | 1.9 (1.2) | 2.4 (1.4) | 1.9 (1.3) | <.001 |
| Arm problems | 0.6 (0.9) | 0.6 (0.8) | 1.0 (1.2) | 0.7 (1.0) | .01 |
a
Two-sided Ps less than .05 were considered statistically significant; analyses used analysis of variance for continuous variables and chi-square tests for categorical variables. BCPT = Breast Cancer Prevention Trial, higher score indicates greater severity of symptom; FSI = Fatigue Severity Inventory, higher score indicates more fatigue; ISI = Insomnia Severity Index, higher score indicates greater insomnia; MCS = mental component scale; PCS = physical component scale; SF-12 = Short Form Health Survey 12 item, higher is better.