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Pharmacokinetic Parameters Used in the Monte Carlo Simulation
| Normal Renal Function | Renal Impairment | |
|---|---|---|
| Age (year) | 47.3±17.7 | 54.2±17.5 |
| Weight (kg) | 68.6±11.6 | 66.9±11.1 |
| CrCL (mL/min) | 123(81.6–315.2) | 42(15.6–77.6) |
| V1 | 6.87 | 1.12 |
| V2 | 11.97 | 1.8 |
| CL | 2.19 | 1.58 |
| Q | 13.83 | 10.28 |
| Omega2v1 | 0.78 | 0.38 |
| Omega2v2 | 0.32 | 0.74 |
| Omega2cl | 0.22 | 0.26 |
| Omega2q | 0.68 | NA |
