Table 3.
Simulated Cmin and Cmax of PMB Dosing Regimens at Steady State
Renal Function | WT (kg) | Maintenance Dose | Cmin | Cmax | ||
---|---|---|---|---|---|---|
Median (mg/L) | Range (5–95%) (mg/L) | Median (mg/L) | Range (5–95%) (mg/L) | |||
Normal renal function | 50 | PMB 1 mg/kg q12h | 0.94 | 0.12–3.04 | 4.55 | 2.39–8.45 |
PMB 1.25 mg/kg q12h | 1.18 | 0.16–3.81 | 5.69 | 2.99–10.56 | ||
PMB 1.5 mg/kg q12h | 1.41 | 0.19–4.57 | 6.83 | 3.59–12.67 | ||
PMB 2 mg/kg q12h | 1.88 | 0.25–6.09 | 9.10 | 4.78–16.89 | ||
65 | PMB 1 mg/kg q12h | 1.22 | 0.16–3.96 | 5.92 | 3.11–10.98 | |
PMB 1.25 mg/kg q12h | 1.53 | 0.20–4.95 | 7.40 | 3.89–13.72 | ||
PMB 1.5 mg/kg q12h | 1.83 | 0.24–5.94 | 8.87 | 4.66–10.47 | ||
PMB 2 mg/kg q12h | 2.45 | 0.32–7.91 | 11.83 | 6.22–21.96 | ||
80 | PMB 1 mg/kg q12h | 1.50 | 0.20–4.87 | 7.28 | 3.83–13.51 | |
PMB 1.25 mg/kg q12h | 1.88 | 0.25–6.09 | 9.10 | 4.78–16.89 | ||
PMB 1.5 mg/kg q12h | 2.26 | 0.30–7.31 | 10.92 | 5.74–20.27 | ||
PMB 2 mg/kg q12h | 3.01 | 0.40–9.74 | 14.56 | 7.65–27.03 | ||
– | PMB 60 mg q12h | 1.13 | 0.15–3.65 | 5.46 | 2.87–10.14 | |
– | PMB 80 mg q12h | 1.51 | 0.20–4.87 | 7.28 | 3.83–13.51 | |
– | PMB 100 mg q12h | 1.88 | 0.25–6.09 | 9.10 | 4.78–16.89 | |
Renal impairment | 50 | PMB 1 mg/kg q12h | 0.07 | 0.00002–1.16 | 12.94 | 7.56–22.63 |
PMB 1.25 mg/kg q12h | 0.09 | 0.00003–1.45 | 16.18 | 9.45–28.29 | ||
PMB 1.5 mg/kg q12h | 0.11 | 0.00003–1.74 | 19.41 | 11.35–33.95 | ||
PMB 2 mg/kg q12h | 0.15 | 0.00004–2.33 | 25.88 | 15.13–45.27 | ||
65 | PMB 1 mg/kg q12h | 0.10 | 0.00003–1.51 | 16.82 | 9.83–29.43 | |
PMB 1.25 mg/kg q12h | 0.12 | 0.00004–1.89 | 21.03 | 12.29–36.78 | ||
PMB 1.5 mg/kg q12h | 0.14 | 0.00004–2.27 | 25.23 | 14.75–44.14 | ||
PMB 2 mg/kg q12h | 0.19 | 0.00006–3.02 | 33.64 | 19.67–58.85 | ||
80 | PMB 1 mg/kg q12h | 0.12 | 0.00004–1.86 | 20.71 | 12.10–36.20 | |
PMB 1.25 mg/kg q12h | 0.15 | 0.00004–2.33 | 25.88 | 15.13–45.27 | ||
PMB 1.5 mg/kg q12h | 0.18 | 0.00005–2.79 | 31.06 | 18.15–54.32 | ||
PMB 2 mg/kg q12h | 0.23 | 0.00007–3.72 | 41.41 | 24.20–72.43 | ||
– | PMB 60 mg q12h | 0.09 | 0.00002–1.40 | 15.53 | 9.08–27.16 | |
– | PMB 80 mg q12h | 0.12 | 0.00003–1.86 | 20.71 | 12.10–36.21 | |
– | PMB 100 mg q12h | 0.15 | 0.00004–2.33 | 25.88 | 15.13–45.27 |
Abbreviations: WT, total body weight; PMB, polymyxin B.