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. 2021 Jun 17;16:4147–4159. doi: 10.2147/IJN.S303829

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© 2021 Hong et al.

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(A) Viabilities of L929 cells treated with blank-NPs and blank-P-NPs, (B) Anti-proliferative effects of Cur-solution, Cur-NPs, and Cur-P-NPs against U251 cells (24 h), (C) Anti-proliferation effects of Cur-solution, Cur-NPs, and Cur-P-NPs against U251 cells (48 h), (D) Fluorescence intensity of U251 cells. (**P < 0.01, ***P < 0.001).

Abbreviations: Blank-NPs, blank hybridized nanoparticles; Blank-P-NPs, blank enzyme-targeted hybridized nanoparticles; Cur-Solution, curcumin dissolved in DMSO:H₂O at 1:1000 (v:v); Cur-NPs, Cur-loaded hybridized nanoparticles; Cur-P-NPs, Cur-loaded enzyme-targeted hybrid nano-delivery systems; DMEM, Dulbecco’s modified Eagle’s medium.