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. 2021 Jun 21;9(7):E1086–E1096. doi: 10.1055/a-1381-7013

Table 3. Short-term outcomes after endoscopic resection of EGCs according to the histological type.

Characteristics Pure differentiated Pure undifferentiated Mixed type P value 1
N = 520 N = 13 Total (N = 37) Differentiated predominantly (N = 26) Poor differentiated predominantly (N = 11)
Size (cm)  18 (10,26) 22 (20,27) 25 (18,38) 25 (20,38) 20 (15,40)       0.001
Depth  < 0.001

  • pM

 465 (89.4 %) 11 (84.6 %) 18 (48.7 %) 13 (50.0 %)  5 (45.5 %)

  • pSM1

  35 (6.7 %)  2 (15.4 %)  6 (16.2 %)  4 (15.4 %)  2 (18.2 %)

  • pSM2

  18 (3.5 %)  0 (0) 11 (29.7 %)  8 (30.8 %)  3 (29.7 %)

  • Undetermined

   1 (0.2 %)  0 (0)  2 (5.4 %)  1 (3.8 %)  1 (9.1 %)
LVI status  < 0.001

  • No

 512 (98.5 %) 13 (100 %) 28 (75.7 %) 21 (80.8 %)  7 (63.6 %)

  • Yes

   7 (1.4 %)  0 (0)  9 (24.3 %)  5 (19.2 %)  4 (36.4 %)

  • Undetermined

   1 (0.1 %)  0 (0)  0 (0)  0 (0)  0 (0)
UL  < 0.001

  • No

 512 (98.5 %) 10 (76.9 %) 34 (91.9 %) 23 (88.5 %) 11 (100 %)

  • Yes

   8 (1.5 %)  3 (23.1 %)  3 (8.1 %)  3 (11.5 %)  0 (0)
Horizontal margin involvement  < 0.001

  • Negative

 486 (93.5 %)  9 (69.2 %) 30 (81.1 %) 21 (80.8 %)  9 (81.8 %)

  • Positive

  32 (6.2 %)  4 (30.8 %)  7 (18.9 %)  5 (19.2 %)  2 (18.2 %)

  • Undetermined

   2 (0.4 %)  0 (0)  0 (0)  0 (0)  0 (0)
Vertical margin involvement  < 0.001

  • Negative

 516 (99.2 %) 13 (100 %) 33 (89.2 %) 25 (96.1 %)  8 (72.7 %)

  • Positive

   2 (0.4 %)  0 (0)  4 (10.8 %)  1 (3.9 %)  3 (27.3 %)

  • Undetermined

   1 (0.2 %)  0 (0)  0 (0)  0 (0)  0 (0)
Complete resection  < 0.001

  • Yes

 484 (93.1 %)  9 (69.2 %) 27 (73.0 %) 20 (76.9 %)  7 (63.6 %)

  • No

  36 (6.9 %)  4 (30.8 %) 10 (27.0 %)  6 (23.1 %)  4 (36.4 %)
Additional treatment for noncurative resection  < 0.001

  • Close follow-up

  25 (39.7 %)  5 (45.4 %)  9 (39.1 %)  8 (50.0 %)  1 (14.3 %）

  • Repeated endoscopic resection

  14 (22.2 %)  1 (9.1 %)  1 (4.4 %)  1 (6.2 %)  0 (0)

  • Surgery

  24 (38.1 %)  5 (45.5 %) 13 (56.5 %)  7 (43.8 %)  6 (85.7 %）

pM, intramucosal; pSM1, depth of invasion < 500 um from the muscularis mucosae; pSM2, depth of invasion ≥ 500 um from the muscularis mucosae; LVI, lymphatic vessel infiltration; UL, ulceration. EGC, early gastric cancer.

1

P values were obtained by comparing three groups including mixed type EGC, pure differentiated, and pure undifferentiated EGCs.