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. 2021 Jun 21;81(6):666–678. doi: 10.1055/a-1471-4063

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The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ )

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.

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Abb. 1 — Die zytotoxische Aktivität von therapeutischen Antikörpern kann durch Engineering-Strategien erhöht werden. Verschiedene Ansätze werden verfolgt: (1) Fc-Engineering: Optimierung der Fc-Domäne durch den Austausch von Aminosäuren im Proteinrückgrat (z. B. Tafasitamab) oder Änderung des Glykosylierungsmusters (z. B. Obinutuzumab). Gelb = Aminosäureaustausch, hellgrau = Zuckerstrukturen. (2) Bispezifische Antikörper zur Rekrutierung von Immuneffektorzellen, z. B. T-Zellen (z. B. Blinatumomab). (3) Antikörper-Wirkstoff-Konjugate, die zusätzlich zu ihrem natürlichen Wirkmechanismus eine zytotoxische Substanz zur Tumorzelle transportieren und dort abliefern. Pink = Linker, lila = toxische Substanz (sog. Payload). PDB-Strukturdatei zur Verfügung gestellt von M. Clark 28 .