Table 3.
Multivariate regression analysis of liver enzyme levels with cardiometabolic diseases.
| Variables | ALT | AST | ALT/AST ratio | GGT | ALP |
|---|---|---|---|---|---|
| β (95% CI) | β (95% CI) | β (95% CI) | β (95% CI) | β (95% CI) | |
| Chol | |||||
| Crude | 0.03 (0.02–0.04) | 0.01 (0.01–0.02) | 0.0004 (0.0002–0.0006) | 0.07 (0.06–0.08) | 0.23 (0.19–0.26) |
| Adjusted model | 0.04 (0.03–0.05) | 0.01 (0.01–0.02) | 0.0008 (0.0006–0.001) | 0.07 (0.05–0.08) | 0.13 (0.09–0.18) |
|
| |||||
| TG | |||||
| Crude | 0.03 (0.02-0.03) | 0.009 (0.007-0.01) | 0.0009 (0.0008-0.001) | 0.05 (0.04-0.05) | 0.09 (0.08-0.11) |
| Adjusted model | 0.02 (0.01–0.02) | 0.005 (0.002-0.008) | 0.0007 (0.0005-0.0008) | 0.04 (0.03-0.05) | 0.06 (0.04–0.08) |
|
| |||||
| LDL | |||||
| Crude | 0.05 (0.04–0.06) | 0.02 (0.01–0.03) | 0.0005 (0.0005–0.001) | 0.1 (0.09–0.1) | 0.28 (0.23–0.33) |
| Adjusted model | 0.06 (0.04–0.08) | 0.02 (0.01–0.03) | 0.0009 (0.0005–0.001) | 0.08 (0.06–0.1) | 0.17 (0.10–0.24) |
|
| |||||
| HDL | |||||
| Crude | -0.20 (-0.22–-0.17) | -0.02 (-0.0–-0.01) | -0.007 (-0.007–-0.006) | -0.16 (-0.20–-0.13) | -0.26 (-0.38–-0.10) |
| Adjusted model | -0.05 (-0.10–-0.01) | 0.01 (-0.01–0.04) | -0.003 (-0.004–-0.002) | -0.06 (-0.12–-0.003) | -0.28 (-0.44–-0.10) |
|
| |||||
| FBS | |||||
| Crude | 0.04 (0.03–0.05) | -0.007 (-0.01–-0.001) | 0.002 (0.002–0.002) | 0.09 (0.08–0.11) | 0.31 (0.27–0.36) |
| Adjusted model | 0.04 (0.03–0.05) | -0.008 (-0.01–0.0001) | 0.002 (0.002–0.002) | 0.09 (0.07–0.11) | 0.27 (0.21–0.32) |
|
| |||||
| Waist circumference | |||||
| Crude | 0.17 (0.14–0.19) | 0.01 (-0.007–0.02) | 0.007 (0.006–0.007) | 0.22 (0.18–0.26) | 0.47 (0.35–0.59) |
| Adjusted model | 0.05 (-0.01–0.11) | 0.01 (-0.02–0.05) | 0.001 (0.0004–0.003) | 0.09 (0.003–0.18) | 0.37 (0.11–0.64) |
|
| |||||
| SBP | |||||
| Crude | 0.05 (0.04–0.07) | 0.02 (0.01–0.03) | 0.001 (0.0009–0.001) | 0.11 (0.08–0.13) | 0.52 (0.45–0.60) |
| Adjusted model | 0.03 (0.006–0.05) | 0.01 (0.001–0.03) | 0.0002 (-0.0002–0.0008) | 0.05 (0.01–0.08) | 0.34 (0.24–0.45) |
|
| |||||
| DBP | |||||
| Crude | 0.10 (0.07–0.13) | 0.04 (0.02–0.06) | 0.002 (0.001–0.003) | 0.18 (0.14–0.22) | 0.75 (0.62–0.88) |
| Adjusted model | 0.04 (0.08–0.08) | 0.02 (-0.0002–0.05) | 0.0002 (-0.0007–0.001) | 0.09 (0.03–0.15) | 0.51 (0.34–0.68) |
ALT: alanine aminotransferase; AST: aspartate aminotransferase; GGT: gamma-glutamyl transferase; ALP: alkaline phosphatase; Chol: cholesterol; TG: triglyceride; LDL: low-density lipoprotein; HDL: high-density lipoprotein; FBS: fast blood glucose; SBP: systolic blood pressure; DBP: diastolic blood pressure. ∗Adjusted model for gender, age, smoking status, physical activity, and BMI.