Table 1.
Clinicopathologic characteristics of lung adenocarcinomas with MLCs.
| Case no. | Age (years)/sex/smoking | Location | Size (cm) | Histologic findings | Treatment | TNM stage | Follow-up (months) | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Proportion of MLCs (%) | Predominant component | Other components | STAS | Visceral pleural invasion | |||||||
| 1 | 50/F/no | LLL | 2.2 | 10 | Acinar | Micropapillary | — | — | Lobectomy | T1N1M0 | AWT (45) |
| 2 | 46/F/no | RLL | 2.5 | 15 | Acinar | Micropapillary | + | — | Lobectomy | T1N0M0 | NET (38) |
| 3 | 68/F/no | LUL | 3.0 | 20 | Acinar | Micropapillary | — | + | Lobectomy | T2N0M0 | NET (37) |
| 4 | 46/F/no | RUL | 2.5 | 5 | Acinar | Lepidic/micropapillary | — | — | Lobectomy | T1N0M0 | NET (37) |
| 5 | 48/M/yes | LUL | 2.0 | 5 | Lepidic | Acinar | + | — | Lobectomy | T1N1M0 | NET (34) |
| 6 | 66/M/yes | LLL | 3.2 | 15 | Lepidic | Papillary/cribriform | — | — | Lobectomy | T2N1M0 | DOT(22) |
| 7 | 55/F/no | RLL | 3.1 | 10 | Lepidic | Papillary | — | — | Lobectomy | T2N0M0 | NET (33) |
| 8∗ | 51/M/no | RLL | 1.2 | 15 | Lepidic | Acinar | — | — | Lobectomy | T1N1M0 | NET (32) |
| 9 | 56/F/no | LUL | 1.0 | 20 | Papillary | Lepidic | — | — | Lobectomy | T1N0M0 | NET (32) |
| 10 | 53/M/yes | LLL | 2.0 | 15 | Lepidic | Cribriform | — | + | Lobectomy | T2N1M0 | DOT (3) |
| 11 | 68/F/no | LUL | 2.5 | 25 | Lepidic | Acinar | — | — | Lobectomy | T1N0M0 | NET (30) |
| 12 | 60/M/no | LLL | 2.0 | 5 | Lepidic | Acinar/micropapillary | — | — | Wedge resection | T1N0M0 | NET (30) |
| 13 | 56/M/yes | LLL | 3.4 | 15 | Lepidic | Papillary/micropapillary/acinar | + | + | Lobectomy | T2N1M0 | NET (29) |
| 14 | 68/F/yes | RML | 1.3 | 5 | Lepidic | Cribriform/micropapillary | + | — | Lobectomy | T1N0M0 | NET (28) |
| 15 | 55/F/no | LUL | 2.5 | 35 | Acinar | Micropapillary | + | — | Lobectomy | T1N0M0 | Lost to follow-up |
| 16 | 70/F/no | RUL | 2.3 | 50 | Acinar | None | — | + | Wedge resection | T2N0M0 | NET (28) |
| 17 | 61/M/no | RUL | 3.0 | 10 | Acinar | Micropapillary | — | — | Lobectomy | T1N1M0 | NET (27) |
| 18 | 48/F/no | LUL | 2.8 | 5 | Lepidic | Acinar | — | + | Lobectomy | T2N0M0 | NET (27) |
| 19 | 66/F/yes | LUL | 2.5 | 10 | Acinar | Lepidic | — | + | Lobectomy | T2N0M0 | NET (27) |
| 20 | 68/F/no | RLL | 1.7 | 5 | Papillary | Lepidic | — | — | Lobectomy | T1N0M0 | NET (26) |
AWT: alive with tumor (recurrence); DOT: died of tumor; F: female; LLL: left lower lobe; LUL: left upper lobe; M: male; NET: no evidence of tumor; RLL: right lower lobe; RML: right middle lobe; RUL: right upper lobe; STAS: spread through air spaces. ∗This case was a minimally invasive adenocarcinoma.