Table 1.
Baseline clinical characteristics of patients in the Sepsis + ARDS group who were survivors and non-survivors
| Parameter | Non-survivors (n = 42) |
Survivors (n = 119) |
P value |
|---|---|---|---|
| Age (years) | 68 ± 13 | 65 ± 16 | 0.137 |
| Gender (male/female) | 23/19 | 84/35 | 0.062 |
| Coronary heart disease | 13 (31.1%) | 38 (31.9%) | 0.907 |
| Hypertension | 12 (28.6%) | 36 (30.2%) | 0.838 |
| Type 2 diabetes | 5 (11.9%) | 13 (10.9%) | 0.862 |
| Chronic renal failure | 3 (7.1%) | 8 (6.7%) | 0.926 |
| COPD | 12 (28.6%) | 39 (32.8%) | 0.615 |
| Length of stay | 10 (2–22) | 9 (3–21) | 0.578 |
| Mean arterial pressure (mmHg) | 68 (35–116) | 87 (48–120) | < 0.001 |
| Respiratory rate (per min) | 24 (12–40) | 22 (13–38) | 0.125 |
| Heart rate (bpm) | 110 ± 33 | 98 ± 20 | 0.022 |
| Temperature (°C) | 38.1 ± 1.4 | 37.2 ± 0.8 | 0.019 |
| White blood count (109/L) | 15.0 ± 6.6 | 14.3 ± 7.2 | 0.682 |
| Platelet count (109/L) | 131 (17–364) | 178 (35–473) | 0.055 |
| Hematocrit (%) | 31.3 ± 7.0 | 35.4 ± 5.7 | 0.050 |
| PaO2/FiO2 (mmHg) | 152.1 ± 55.7 | 164.6 ± 54.5 | 0.021 |
| Total bilirubin (μmmol/L) | 19.5 (4.6–124.7) | 19.0 (4.8–98.5) | 0.183 |
| Creatinine (μmmol/L) | 144.0 (44.9–1477.9) | 96.4 (33.7–507.6) | 0.009 |
| Lactate (mmol/L) | 3.7 (0.9–18.0) | 2.7 (1.2–5.6) | < 0.0001 |
| GCS score | 9 (3–15) | 11 (3–15) | < 0.0001 |
| SOFA score | 11 (3–21) | 6 (2–18) | < 0.0001 |
| CRP (mg/L) | 134.9 (18.6–468.0) | 100.7 (9.8–200.0) | < 0.0001 |
| PCT (ng/mL) | 16.96 (1.70–200.00) | 3.07 (0.15–200.0) | < 0.0001 |
| IL-6 (pg/mL) | 367.7 (37.3–498.2) | 89.6 (2.9–462.6) | < 0.0001 |
| TNF-α (pg/mL) | 63.9 (11.1–215.4) | 12.3 (5.8–102.1) | < 0.0001 |
| IL-10 (pg/mL) | 597.6 (68.0–798.7) | 108.6 (10.7–657.9) | < 0.0001 |
| FGF21 (pg/mL) | 3574.7 (327.3–6978.5) | 986.6 (32.3–6121.3) | < 0.0001 |
COPD chronic obstructive pulmonary disease