Figure 6.

Neutralizing mAbs as pre-exposure prophylaxis in k18-hACE2 mice

CV1-1, CV1-30, and CV2-75 were assessed to see whether they could confer protection in a mouse model.

(A) Experimental timeline.

(B) Number of PFUs in the lungs 2 days following challenge. Error bars indicate SD.

(C) Viral RNA in lung tissue 2 days after challenge was measured by qPCR and normalized to GAPDH expression. Error bars indicate SD.

(D) Kaplan-Meyer survival curve of the viral load/titer in the lungs of remaining mice comparing the various treatment groups.

Statistics were determined by one-way ANOVA with Dunnett’s multiple comparison test. ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001, ^∗∗∗∗p < 0.0001.