Table 1.

Number of carriers of rare non-silent CDH1 germline variants predicted to be deleterious in our cohort of glioma families compared to controls

	Glioma families	Controls	p value
CDH1 variant
Carriers	2 (13.3%)	1031 (1.7%)	0.0267*
Non-carriers	13	59,115
Total	15	60,146

Given are all carriers and non-carriers of rare (MAF ≤ 0.5%) non-silent CDH1 germline variants that are predicted to be deleterious by one of two prediction tools (SIFT or PolyPhen-2 according to the gnomAD database) in our glioma families compared to gnomAD dataset v2.1.1 (controls) (http://gnomad.broadinstitute.org/)

*p ≤ 0.05 (two-tailed Fisher’s exact test)