Table 1.

Clinicopathologic features of 1117 patients treated with transurethral resection of the bladder (TURB) for NMIBC, stratified by the De Ritis ratio (DRR)

Parameters	All	DRR < 1.2	DRR ≥ 1.2	p value
Total, n (%)	1 117	712 (63.7)	405 (36.3)
Age, median (IQR)	67 (58–74)	66 (58–74)	67 (59–74)	0.4
Female gender, n (%)	262 (23.5)	178 (25.0)	84 (20.7)	0.1
Tumor stage, n (%)				0.7
pTa	653 (58.5)	413 (58.0)	240 (59.3)
pTis	21 (1.9)	12 (1.7)	9 (2.2)
pT1	443 (39.6)	287 (40.3)	156 (38.5)
Tumor grade, n (%)				0.7
G1	231 (20.7)	151 (21.2)	80 (19.7)
G2	398 (35.6)	247 (34.7)	151 (37.3)
G3	488 (43.7)	314 (44.1)	174 (43.0)
Concomitant carcinoma in situ, n (%)	66 (5.9)	41 (5.8)	25 (6.2)	0.8
Tumor size, n (%)				0.6
< 1 cm	368 (32.9)	242 (34.0)	126 (31.1)
1–3 cm	448 (40.1)	284 (40.0)	164 (40.5)
> 3 cm	301 (27.0)	186 (26.0)	115 (28.4)
Number of tumors, n (%)				0.2
1 tumor	718 (64.3)	469 (65.9)	249 (61.5)
1–7 tumors	297 (26.6)	176 (24.7)	121 (29.9)
≥ 8 tumors	102 (9.1)	67 (9.4)	35 (8.6)
Smoker, n (%)				0.1
Never	272 (24.4)	186 (26.1)	86 (21.2)
Former	331 (29.6)	216 (30.4)	115 (28.4)
Current	514 (46.0)	310 (43.5)	204 (50.4)
Intravesical therapy, n (%)	493 (44.1)	293 (41.2)	200 (49.4)	0.01
Type of intravesical therapy, n (%)				0.001
No intravesical therapy	624 (55.9)	419 (58.8)	205 (50.6)
Adjuvant BCG	300 (26.9)	158 (22.2)	142 (35.1)
Adjuvant chemotherapy	48 (4.3)	30 (4.2)	18 (4.4)
Early single instillation	145 (12.9)	105 (14.8)	40 (9.9)
Prior recurrence, n (%)				0.1
Primary tumor	931 (83.3)	584 (82.0)	347 (85.7)
Recurrent tumor	186 (16.7)	128 (18.0)	58 (14.3)
EORTC risk for recurrence, n (%)				0.9
Low	443 (39.7)	283 (39.7)	160 (39.5)
Intermediate	524 (46.9)	333 (46.8)	191 (47.2)
High	150 (13.4)	96 (13.5)	54 (13.3)
EORTC risk for progression, n (%)				0.6
Low	558 (49.9)	350 (49.2)	208 (51.4)
Intermediate	432 (38.7)	283 (39.7)	149 (36.8)
High	127 (11.4)	79 (11.1)	48 (11.8)

Statistical significance was set at p < 0.05