Table 1.

Neuropathological diagnosis

Neuropathological diagnosis	Anatomical distribution	Neuropathological hallmark	Tau isoform
AD	Neocortex and limbic regions	Neurofibrillary tangles (NFTs), neuropil threads and dystrophic neurites	3R + 4R
PiD	Frontal, temporal, and parietal lobes	Cytoplasmic spherical structures, termed Pick Bodies	3R
CBD	Focal atrophy of superior frontal gyrus and parietal lobe	Small-NFTs, corticobasal bodies (Fig. 3b) and diffuse granular tau inclusions. Occasional Pick bodies are observed. The most specific pathology is the astrocytic plaque which appears as a circular or ring-shaped collection of argyrophilic tau-positive cell processes	4R
PSP	Subthalamic nucleus, superior cerebellar peduncle and hilum of cerebellar dentate nucleus	Globose NFTs, tufted astrocytes (Fig. 3c) and oligodendroglial coiled bodies	4R
AGD	Amygdala, limbic cortex, mesial temporal lobe, and temporal neocortex	Small dot-like spindle-shaped structures, termed grains. Oligodendroglial coiled bodies and pre-tangles	4R
CTE	Varying degrees of atrophy in frontal and temporal lobes. Often found in the depths of sulci	NFTs (Fig. 3f) and astrocytic tangles	3R + 4R