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. 2021 Apr 19;142(1):179–189. doi: 10.1007/s00401-021-02302-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Histology of glioblastoma with primitive neuronal component. Cases present with high nuclear-to-cytoplasmic ratio and frequent mitoses in the areas with embryonal phenotype (a, d, g). GFAP expression is lacking in these tumor regions (b, e). Glial areas with retained GFAP expression b, e and lower proliferation index c can be sharply demarcated from GFAP negative areas. Lacking cytokeratin expression in GFAP negative areas (f), but nuclear positivity for p53 (h) and TTF1 (clone EP229) (i). Scale bar 200 µm